Mechanical suspensions for space applications

Characteristics of mechanical suspensions for moving components of aerospace system

Sixth Aerospace Mechanisms Symposium

Design and development of mechanisms for spacecraft components - conference

One dimensional modelling of failure in laminated plates by delamination buckling

When low speed objects impact composite laminated plates delamination may result. Under inplane compression such delaminations may buckle and tend to enlarge the delaminated area which can lead to loss of global plate stability. This process is modelled here in a first attempt by a delaminating beam-column wherein the local delamination growth, stability and arrest are governed by a fracture mechanics-based energy release rate criterion

Polyamine metabolism in compensatory renal growth

Compensatory renal growth, following renal mass extirpation, is accompanied by multiple biochemical alterations including increased nucleic acid, protein, and polyamine synthesis. The aliphatic polyamines-putrescine, spermidine, and spermine are found in most living organisms and appear to participate in many forms of augmented growth including embryonic, regenerative, hormone-induced, and neoplastic [1–3]. While the precise biochemical function of these compounds has not been defined, increased levels of polyamines and their biosynthetic enzymes occur in association with enhanced nucleic acid and protein synthesis in rapidly growing tissues [3–6]. Polyamines apparently contribute to nucleic acid accumulation by promoting biosynthesis and retarding degradation [6–8]. The decarboxylation of ornithine to putrescine is the rate-limiting step in polyamine synthesis. The catalyst, ornithine decarboxylase, is very inducible and has a short half-life in both normal and regenerating liver (10 to 11 min) [5]. Changes in enzyme activity precede or occur simultaneously with increases in RNA, DNA, and protein concentrations [3].In this study, alterations in renal polyamine synthesis were investigated in conjunction with other evidences of stimulated kidney growth following unilateral nephrectomy. These data are discussed in the context of previous observations regarding polyamine biosynthesis during enhanced renal growth

Expression of Stem Cell Markers in the Human Fetal Kidney

In the human fetal kidney (HFK) self-renewing stem cells residing in the metanephric mesenchyme (MM)/blastema are induced to form all cell types of the nephron till 34th week of gestation. Definition of useful markers is crucial for the identification of HFK stem cells. Because wilms' tumor, a pediatric renal cancer, initiates from retention of renal stem cells, we hypothesized that surface antigens previously up-regulated in microarrays of both HFK and blastema-enriched stem-like wilms' tumor xenografts (NCAM, ACVRIIB, DLK1/PREF, GPR39, FZD7, FZD2, NTRK2) are likely to be relevant markers. Comprehensive profiling of these putative and of additional stem cell markers (CD34, CD133, c-Kit, CD90, CD105, CD24) in mid-gestation HFK was performed using immunostaining and FACS in conjunction with EpCAM, an epithelial surface marker that is absent from the MM and increases along nephron differentiation and hence can be separated into negative, dim or bright fractions. No marker was specifically localized to the MM. Nevertheless, FZD7 and NTRK2 were preferentially localized to the MM and emerging tubules (<10% of HFK cells) and were mostly present within the EpCAMneg and EpCAMdim fractions, indicating putative stem/progenitor markers. In contrast, single markers such as CD24 and CD133 as well as double-positive CD24+CD133+ cells comprise >50% of HFK cells and predominantly co-express EpCAMbright, indicating they are mostly markers of differentiation. Furthermore, localization of NCAM exclusively in the MM and in its nephron progenitor derivatives but also in stroma and the expression pattern of significantly elevated renal stem/progenitor genes Six2, Wt1, Cited1, and Sall1 in NCAM+EpCAM- and to a lesser extent in NCAM+EpCAM+ fractions confirmed regional identity of cells and assisted us in pinpointing the presence of subpopulations that are putative MM-derived progenitor cells (NCAM+EpCAM+FZD7+), MM stem cells (NCAM+EpCAM-FZD7+) or both (NCAM+FZD7+). These results and concepts provide a framework for developing cell selection strategies for human renal cell-based therapies

The patriotism of gentlemen with red hair: European Jews and the liberal state, 1789–1939

European Jewish history from 1789–1939 supports the view that construction of national identities even in secular liberal states was determined not only by modern considerations alone but also by ancient patterns of thought, behaviour and prejudice. Emancipation stimulated unprecedented patriotism, especially in wartime, as Jews strove to prove loyalty to their countries of citizenship. During World War I, even Zionists split along national lines, as did families and friends. Jewish patriotism was interchangeable with nationalism inasmuch as Jews identified themselves with national cultures. Although emancipation implied acceptance and an end to anti-Jewish prejudice in the modern liberal state, the kaleidoscopic variety of Jewish patriotism throughout Europe inadvertently undermined the idea of national identity and often provoked anti-Semitism. Even as loyal citizens of separate states, the Jews, however scattered, disunited and diverse, were made to feel, often unwillingly, that they were one people in exile